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A compound synthesized from tryptophan, it is a precursor to the neurotransmitter
serotonin. Serotonin is found in the brain, blood platelets', and cells of the
gastrointestinal tract. Because serotonin is found in the brain and central nervous system
it has many implications in problem areas. The function of Prozac, and many other antidepressant drugs, is to increase
the availability of serotonin in synapses in certain key areas of the brain. However,
these drugs may present many unpleasant and dangerous side effects. Since the availability
of tryptophan is restricted by the FDA, many research scientists have discovered that
5-HTP compares favorably to various antidepressant drugs.
Other symptoms of serotonin deficiency can include: carbohydrate cravings, migraines, obsessive-compulsive behaviors, and other behavioral disorders.
Restoring serotonin is the basis, as mentioned earlier, for one of the most popular classes of drugs prescribed today, the selective serotonin reuptake inhibitors (SSRls). These drugs, including Prozac®, Zoloft®, Paxil®, and others, are widely used to treat depression, anxiety, and insomnia. They are effective because they increase the availability of serotonin in synapses in certain key areas of the brain by blocking its inactivation, but they do not increase serotonin.
100mg - 30 capsules----------------$39.90 Use Order Form to order
"I note that you sell the supplement 5-HTP. The data you provide about it is quite interesting.
I've gleaned some additional information concerning this important supplement. The following is a brief fact sheet that I hope will be of interest.
Larry Godwin, Ph.D.
5-HTP is a metabolite of the amino acid tryptophan. It is the direct precursor of the neurotransmitter serotonin.(1)
Serotonin is an inhibitory neurotransmitter,(5) the one associated with calm. It soothes and comforts us from worry and stress. Stress causes the heightened release of serotonin, and if the stress lasts too long, it leads to serotonin depletion. Research strongly implies that boosted brain serotonin serves as a "stress immunizer."(6)
When it comes to the ups and downs of mood disorders, serotonin seems to play the role of regulator.(2) Low serotonin levels are associated with irritability, aggression, impatience, and anxiety.(6) Evidence suggests that serotonin inhibits aggressive behavior in experimental animals and humans.(3) A lack of good parental care, e.g., abusive parenting while growing up, can permanently damage the serotonin system.(6)
Abundant laboratory research suggests there is a deficiency of serotonin or serotonin activity in the brains of most depressed persons., Suicidal patients show a significant decrease in serotonin levels.(3) Most antidepressant drugs, including tricyclics, lithium, MAO inhibitors, and SSRI's (Prozac, Zoloft, Paxil, and Luvox), have this in common: they boost serotonin levels.(2)
5-HTP differs from tryptophan in that it slightly increases the activity of an energizing neurotransmitter, norepinephrine, as well as the calming one, serotonin.(1) In some clinical trials, 5-HTP outperformed tryptophan in treating mood disorders.(2) The greater the agitation associated with depression, the more likely the response to 5-HTP.(3)
The suggested dosage range of 5-HTP is 50-1200 mg. per day; its usual range is 100-600 mg.(2) However, some depressed persons find relief from a daily dose as small as 25 mg., which involves splitting the purchased capsules or tablets.
For some people, 5-HTP has an extremely narrow therapeutic window. The proper dosage may lie within a range as small as 10-25 mg. per day.(1) Side effects of too high a dose may include hypomania, dermatitis, and increased aggressiveness.(2)
A conservative starting dose for 5-HTP is 25 mg. a day. Many people notice a favorable mood effect within one or two days of beginning supplementation. Gradually boosting the dose by 25 mg. every four days increases the chances of finding a person's therapeutic window.
As with tryptophan, it is important to take 5-HTP away from any protein food.(4) One product manufacturer suggests taking it 45 minutes before or three hours after a protein meal.
References 1. Baumel, Syd, 1995, Dealing with Depression.Naturally. (Keats) 2. Saumel, Syd, 1997, Serotonin: How to Naturally Harness the Power Behind Prozac and Phen/Fen. (Keats) 3. Braverman, Eric, M.D., 1997, The Healing Nutrients Within. (Keats) 4. Chaitow, Leon, 1985, Amino Acids In Therapy. (Thorsons Publishersl 5. Erdmann, Robert, 1987, The Amino Revolution. (Fireside) 6. Norden, Michael, M.D., 1996, Beyond Prozac. (Regan/Harper)"
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