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Glutamine

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Glutamine, glutamate  and gamma-amino butyric acid (GABA) are essential amino acids for brain metabolism and function. Glutamine is the precursor of the two most important neurotransmitters: glutamate, an excitatory neurotransmitter, and GABA, an inhibitory neurotransmitter.  GABA can be purchased over-the-counter, however it cannot pass the blood brain barrier and is therefore useless as a neurotransmitter supplement.

Glutamine is the most common free form amino acid in the body. Intense exercise dramatically increases the need for glutamine. While l-glutamine builds, repairs, and maintains muscle tissue, it is also a major source of energy for the entire body – in particular the brain! L-glutamine is essential ingredient in numerous brain functions which are vital to brain metabolism. L-glutamine performs a major role in DNA synthesis and supports the immune system. 

L-glutamine may stimulate the body’s natural hormonal responses to reduce muscle soreness. L-glutamine may also curb cravings for sugars and alcohol, help bolster the nervous system, and to aid in combating depression and fatigue. L-glutamine supports the natural production of growth hormone, which initiates the release of insulin growth factor (IGF-1), which can increase lean muscle mass and bone density while promoting general good health. 



" L-Glutamine, 500 mg, 100 Tablets
Amino Acid Supplement
Free-Form


L-Glutamine, a free-form amino acid, can be converted to glutamic acid. Glutamic acid is a usable energy source for the brain and a precursor to the important inhibitory neurotrans-mitter, GABA (gamma amino butyric acid), L-glutamine also plays an important role in ammonia disposal.



Suggested Use: One tablet daily, only, or as recommended by your health care professional. 

Note: If you are pregnant or breastfeeding, consult your health care professional before using this product. Do not use if either tamper-evident seal is broken or missing. Keep out of reach of children.

Supplement Facts 
Serving Size: 1 Tablet


Amount Per Serving 
L-Glutamine 500 mg +
-----------------------------------------
+ Daily value not established.

Other ingredients: Sorbitol, stearic acid, modified cellulose gum, colloidal silicon dioxide, and magnesium stearate. 

Suitable for Vegetarians: Contains no yeast, dairy, egg, gluten, corn, soy or wheat,. Contains no sugar, starch, salt, preservatives, or artificial color, flavor, or fragrance. 

Recent Scientific Info:
Curr Opin Clin Nutr Metab Care. 2004 Jan;7(1):59-70. Related Articles, Links 


Glutamine: recent developments in research on the clinical significance of glutamine.

Melis GC, ter Wengel N, Boelens PG, van Leeuwen PA.

Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.

PURPOSE OF REVIEW: The aim of this review is to describe the clinical relevance of supplementation of glutamine from the recent literature. First, new basic research is examined and subsequently recent clinical trials and a meta analysis are illustrated. RECENT FINDINGS: Glutamine has a major impact on the functionality of the immune system. It has recently been established that glutamine not only has a protective effect on cells of the immune system, but also on other cells of the body, for instance cardiomyocytes. Evidence is accumulating for an effect of glutamine via glutathione, heat shock proteins as well as taurine. Another area of interest is the way glutamine enhances gut barrier function. More and more research is concentrating on the positive effect of glutamine on the gut-associated lymphoid tissue. SUMMARY: Based on a recent meta-analysis and up-to-date clinical trials, we may conclude that glutamine has a beneficial effect on infectious complications and reduces hospital stay. In critically ill patients glutamine supplementation may reduce morbidity and mortality. The greatest effect was observed in patients receiving high dose parenteral glutamine. A recent study with high dose enteral glutamine demonstrated a reduced mortality in the glutamine supplemented group. In the future more trials with larger numbers of participants are needed, especially with high dose enteral glutamine in the perioperatively and the intensive care unit setting.

Publication Types: 
Review 
Review, Tutorial 

PMID: 15090905 [PubMed - indexed for MEDLINE] 

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