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Pregnenolone is not a steroid but a steroid hormone precursor manufactured in the body from cholesterol. Pregnenolone is converted in the liver to DHEA and Progesterone (and ultimately other hormones such as estrogen, and testosterone). It is important to note that, as we age, the body's natural pregnenolone levels decrease. Therefore, supplemental pregnenolone may play an important role in today's aging population supporting lean body mass, strength, immune health as well as bone and cardiovascular health.

The views expressed by the authors do not necessarily represent the views of The Hormone Shop LLC.    These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, cure, treat or prevent any disease. If pregnant or lactating, consult a physician before using.

Suggested Reading:         
| Pregnenolone : Nature's Feel Good Hormone |
| The Superhormone Promise |

Go to these subjects on this page:  |A History---Arthritis Pain? |  |A History--- Depression? | | Safety |
|A History---Memory and Intelligence ? | | How to use |

The following excerpt is from "The Superhormone Promise", by Dr.William Regelson, M.D. and Carol Colman.

"In recent years we have learned that many cases of depression are actually caused by an imbalance of substances called neurotransmitters, chemicals in the brain that are intricately involved in how we think and feel. For example, Prozac, probably the best known of the antidepressants, works by restoring the normal balance of a neurotransmitter known as serotonin. In addition to performing the routine functions of regular hormones, we now know that superhormones are also similar to neurotransmitters; they are located in the brain and have a profound impact on mental function. That is why we believe that many cases of depression in older people are actual caused by the decline in superhormones and, in particular, pregnenolone and/or DHEA. I believe that restoring the superhormones such as pregnenolone to their youthful levels will prevent many of the cases of depression that occur among older people and that are all too frequently written off as part of the "normal" aging process.
My belief has been confirmed by a recent study conducted by the National Institutes of Mental Health; it showed that people with clinical depression have lower than normal levels of pregnenolone in their cerebral spinal fluid (the fluid that bathes the brain). Although this study did not look specifically at older people, this finding is relevant to anyone who is producing lower than normal levels of pregnenolone, and that is precisely what happens in aging. What is the connection between pregnenolone and depression? Let me explain the theory. The nerve cells in our brains are constantly being bombarded with stimuli and receiving and transmitting information. Our brains contain a neurotransmitter called GABA, which literally cools the brain and protects our nerve cells from burning out in the course of all this activity. GABA performs an important function, but too much GABA may make the brain too sluggish and produce a dampening effect that depresses brain function. It appears that pregnenolone mitigates the effect of GABA and restores balance to the brain. You may remember that in the earlier studies performed on pregnenolone in the 1940s, the researchers noted that the participants reported an enhanced sense of well-being and an improvement in mood. This could also be due to pregnenolone's effect on GABA.
Although there have been no official studies done on the treatment of depression with pregnenolone, based on all we know about this superhormone, I believe that in cases of mild depression pregnenolone should be very helpful and certainly should be tried before bringing on the "heavier guns," stronger medication that can cause substantial side effects. We know that pregnenolone is safe, well tolerated, and causes no known side effects, so it just makes good sense to try it first.
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An Historical Treatment for Arthritis?              
In the 1940s, pregnenolone was used -----as a treatment for rheumatoid arthritis, the disease that causes severe joint pain and fatigue, and that continues to plague millions of sufferers. As you may remember from the chapter on DHEA, rheumatoid arthritis is an autoimmune disease that is more likely to strike as we get older. There is as yet no cure for rheumatoid arthritis, and the symptoms are usually treated with anti-inflammatory medication. Nearly a half-century ago, rheumatoid arthritis patients  took pregnenolone  and reported that they felt less pain and were less tired, and much stronger.  Was it just the placebo effect? (Editor's note)

Despite the fact that pregnenolone showed promise as a treatment for rheumatoid arthritis, all research on pregnenolone as an arthritis treatment ended abruptly in the 1950s. One reason the medical community lost interest was that, like the other superhormones, pregnenolone was a natural substance produced by the body and therefore could not be patented. As a result, no drug company was interested  in investing the time or money to bring pregnenolone to market. As previously mentioned, it is a sad fact of life that in the United States, no matter how effective a substance may be in treating illness or extending and improving the quality of life, if it is not patentable, it stands a good chance of falling by the wayside. Again, that was a primary reason for writing The Melatonin Miracle and for writing this book. I hope to awaken public interest in these extraordinary natural substances; they are doomed to oblivion unless someone steps forward (I feel it must be the government) to fund these important studies.

  Back To Top

There was another reason that pregnenolone was forgotten: It was completely overshadowed by the discovery of an exciting new synthetic cortisone, in the late 1940s; it was thought to be the cure for arthritis. When cortisone was first introduced, it received as much attention  as did penicillin when it launched the antibiotic revolution a decade earlier. Unlike pregnenolone, the effects of which were cumulative and felt over a period of weeks, cortisone also produced almost overnight relief from arthritis symptoms. From the point of view of pharmaceutical companies, which could make real money selling cortisone, and of patients who understandably wanted fast, fast, fast relief, cortisone was a dream come true. The problem is that by the time we woke from the dream and realized that cortisone and its related compounds have some pretty nightmarish side effects-such as a dampening effect on the immune system that makes patients susceptible to infection, and a destructive effect on bone mass, leaving patients vulnerable to osteoporosis-we had forgotten that once upon a time there was a substance called pregnenolone, which produced relief from ------ symptoms much more safely, albeit more gradually.           

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I hope The Superhormone Promise ensures that pregnenolone does not stay forgotten. I want to spread the word that pregnenolone has a vast therapeutic potential, which deserves further investigation. This superhormone is not only a kinder and gentler treatment -----, but it is a proven strategy for enhancing memory and brain function and elevating mood.  These are just some of the things that we know pregnenolone can do, and there are probably many as yet undiscovered uses for this superhormone."

 

List: $9.95
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Pregnenolone : Nature's Feel Good Hormone by Ray Sahelian, MD.
pregnenolone.gif (4571 bytes)

Paperback, 157 pages
Published by Avery Pub Group
To order these books click on the image or go to our Book Store

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Simon & Schuster :

A Book Review by simon & Schuster
The bestselling authors who made melatonin a household word now tell the rest of the story of what is quite possibly our century's greatest medical breakthrough: superhormones. William Regelson, M.D., one of the nation's leading anti-aging doctors, explains how the latest discoveries in the field add up to an exciting revolution in science and medicine that now gives undeniable support to his long-held claim that aging as we know it is neither a necessary nor an inevitable part 

thesuperhormonepromise.gif (4920 bytes)

The Superhormone Promise
by William Regelson, MD
$6.29

of life. Rather, aging is a preventable disease for which we now have a cure at hand-- superhormones. Although melatonin remains the linchpin of the anti-aging movement that is sweeping the country today, there is a whole class of superhormones that can both improve the quality of our lives and extend them by helping us to maintain the health, energy, vigor, and sexual stamina of youth. The authors explain clearly, simply, and convincingly how nature's superhormones work and why it is now possible to stay young, at any age, simply by boosting your superhormones back to their youthful levels. The research is coming out of our nation's best institutions, including Stanford, Johns Hopkins, and the University of Wisconsin, as well as from the labs of leading scientists around the globe. Yet in addition to describing the exciting laboratory results, The Superhormone Promise also enables readers to hear first-hand from the doctors and patients who have already experienced the amazing age-reversing benefits of superhormones. In short, the Superhormone Revolution has already begun, and Dr. Regelson now explains how to make it work for you. The Superhormone Promise provides complete and comprehensive information about each of the superhormones, including up to the minute research on melatonin, DHEA, testosterone, estrogen (including new forms of "designer" estrogens that will soon be available with none of the drawbacks of the current forms of estrogen), progesterone, pregnenolone, thyroid hormone, and growth hormone. Many of the superhormones are available over the counter and the rest are already being prescribed by tens of thousands of doctors across the United States. Information on how to locate doctors in your area who are already using superhormones in their practice is included in the resource section of the book.
Back to Top

 

Pregenenolone - Possibly The Most Powerful Intelligence Enhancing Agent Ever.

Pregnenolone is a hormone precusor that the body normally manufactures using cholesterol as the primary raw material. In the body, it can be converted into a multitude of other hormones including DHEA,  estrogen, testosterone and progesterone.

As is the case with the steroid-hormone precursor DHEA, Pregnenolone levels decline with age.  Many physicians and scientists believe that replacement of pregnenolone to youthful levels is an important step in dealing with the symptoms of aging.   (Other hormones that decline with aging, and can be replaced, include: DHEA, melatonin, testosterone, progesterone and estrogen). 

However, pregnenolone may be one of the most important hormones because it seems to have a balancing effect.  It is a precursor to many other hormones and may be able to bring the levels of other hormones up or down as needed.

100 Times Better Memory Enhancement

Many steroidal hormones have been found to have intelligence-enhancing capabilities, but pregnenolone seems to have truly extraordinary activity.   Pregnenolone was the subject of memory experiments as far back as 40 years ago, and since then has been found to play an important role in long-term memory.  And, in a recent study, pregnenolone was found to be 100 times more effective for memory enhancement than other steroids or steroid-precursors.  Other studies have demonstrated that pregnenolone may improve general cognitive performance, and may be the most potent memory enhancer ever.

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How To Use Pregnenolone

For most uses 10 to 30 mg per day on an empty stomach is about right.   You can adjust the dosage to what feels good for you.  For help in the relief of ---------, quantities as high as 500 mg per day have been used without any adverse effects.

Other benefits of pregnenolone may include:

bullet

Stress reduction and increased resistance to the effects of stress.

bullet

Relief of inflammation

bullet

Improvement of mood and energy

bullet

Reduced symptoms of PMS and menopause

bullet

Improved immunity

bullet

Repairing the structure of the myelin sheath "        
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