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For Historical Purposes Only


| Progesterone Deceptions |  | Dosage |  | Signs & Symptoms Subject to Progesterone Therapy |


Female Hormones in Context
By Raymond Peat, PhD

The views expressed by the author do not necessarily represent the views of The Hormone Shop LLC.    These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, cure, treat or prevent any disease. If pregnant or lactating, consult a physician before using.

"Many myths about female sexuality and health have been built into both medical education and popular culture. Understanding the subject, scientifically, means going against the current of both conventional medicine and alternative medicine. To illustrate the roles of hormones and the various therapeutic approaches, a variety of problem areas, affecting women from childhood to old age, are considered in detail."

Understanding the subject of female sexuality and health scientifically means going against the current of both conventional medicine and alternative medicine. In this book a variety of problem areas affecting women from childhood to old age are considered in detail.  This book may be ordered form Dr. Peat  by writing to:

Raymond Peat
P.O. Box 5764
Eugene, Oregon, 97405
$12 plus $2.50 shipping.
bulletTable of Contents: Part One: Estrogen in Context / Estrogen: The pill-simply dangerous. / Estrogen: The hoax of "replacement"/ Aging ovaries: Not the eggs. / Menopause and its causes. / Not the "female hormone."/ Just one problem: Clots
bulletPart Two: Progesterone in Context / Symptoms that respond to progesterone therapy. / The origins of progesterone therapy/ Antiaging hormones: Steroids in general. / Youth-associated hormones / Thyroid. / Progesterone's biological generality. / Dosage. / An efficient oral therapy / Transdermal therapy for PMS / The progesterone deceptions
bulletPart Three: "Mysterious" Diseases in Context / Preserving tissues: Osteoporosis and the skin / Natural hormones and ------ / The cervical cancer scare and other approaches to cancer / Warburg's cancer theory and thyroid / --------, varicose veins, and epilepsy / Nerves / Alzheimer's disease / Eclampsia in the real organism
bulletPart Four: Some Products in Context / Estriol & phytoestrogens / Using sunlight to enhance life / Unsaturated oils: Toxic and estrogenic / The dangers of iron: Exacerbated by estrogen / Coconut oil / A logical diet / conclusion

Raymond Peat received his PhD in Biology from the University of Oregon, specializing in physiology. He has written Mind and Tissue, Progesterone in Orthomolecular Medicine, Generative Energy, and Nutrition for Women, besides articles in journals. He has taught at the University of Oregon, Urbana College, Montana State University, National College of Naturopathic Medicine, Universidad Veracruzana, and the Universidad Autonoma del Estado de Mexico, and founded Blake College, International University. He does independent research and private endocrine and nutritional consulting.








"In a 10% solution of Progest-E Complex one drop contains about three milligrams of progesterone.
bulletNormally, the body produces 10 to 20 milligrams per day. A quantity of 3 or 4 drops usually brings the blood levels up to the normal range, but this dose can be repeated several times during the day if it is needed to control symptoms.
bulletFor general purposes, it is most economical and effective to take progesterone dissolved in vitamin E orally, for example taking a few drops on the lips and tongue, or rubbing it into the gums. (It is good for the general health of the ----.) These membranes are very thin, and the progesterone quickly enters the blood. When it is swallowed, the vitamin E allows it to be absorbed through the walls of the stomach and intestine, and it can be assimilated along with food, in the chylomicrons, permitting it to circulate in the blood to all of the organs before being processed by the liver.
bulletFor the topical application to sun damaged skin, or acne wrinkles, etc., the oil can be applied directly to the affected area. For topical treatment of --------, -------, -------, or --------, to speed absorption it is best to apply a few drops of olive oil to the area, and then to rub the Progest-E into and around the affected area. Some of the progesterone will be absorbed systemically, but the highest concentration is sustained in the local area, helping to correct the problem."

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A List of Signs and Symptoms That Respond to Progesterone Therapy

This section has been removed at the request of the FDA.  In order to read this portion of Dr. Peat's book you must obtain a copy from the library or purchase a copy of your own. (January 18, 2001).

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In the 1930s, it was demonstrated that estrogen, even in small doses, produced abortions, and that when it is given early enough, even a very small dose will prevent implantation of the fertilized embryo. Progesterone was known, by the early 1940s, to protect against the many toxic effects of estrogen, including abortion, but it was also known as nature's contraceptive, since it prevents pregnancy without harmful side-effects, by different mechanisms, including prevention of sperm entry into the uterus. That is, progesterone prevents the miscarriages which result from excess estrogen,(1,2) but if used before intercourse, it prevents conception, and thus is a true contraceptive, while estrogen is an abortifacient, not a contraceptive.

In the 1950s, there was a search for chemicals which would prevent ovulation. According to Carl Djerassi,(3) drug companies were extremely reluctant to risk a religious backlash against their other products, and so hesitated to market contraceptives. Obviously, the induction of monthly abortions would have been even harder to sell.

According to Djerassi,(3) "Until the middle 1940s it was assumed that progesterone's biological activity was extremely specific and that almost any alteration of the molecule would diminish or abolish its activity." This would obviously discourage interest from the drug companies, who could patent a substance which they had chemically modified, but could not patent a simple natural substance. However, many substances--even non-steroidal chemicals--turned out to have estrogenic action.(4)

By 1942, Hans Selye had demonstrated that natural steroids retain their activity when administered orally. But every drug company with a steroid patent had an obvious interest in having the public believe that there is a reason that the natural steroids cannot be conveniently used. The doctrine that natural steroids are destroyed by stomach acid appeared, was promoted, and was accepted. In the manufacture of progesterone, the precursor steroid is boiled in hydrochloric acid to free it from its glucose residue; no one seriously believed that stomach acid hurts progesterone, except the public.

The real issue is solubility. Hydrocortisone is reasonably soluble in water, but progesterone is extremely insoluble in water, and, though it is vastly more soluble in vegetable oil than in water, it does not stay in solution at room temperature even at the low concentration of I part in 1000 parts of vegetable oil.

When people speak of an allergy to progesterone (or even to penicillin) they generally are not aware of the presence of a very toxic solvent.(5) A few years ago, progesterone was often sold dissolved in benzyl benzoate; the Physician's Desk Reference warned of possible allergic reaction to progesterone. Now, it is supposedly sold dissolved in vegetable oil, with about 10% benzyl alcohol as a bacteriostatic agent. Bacteriostatic water contains 0.9% to 1.9% benzyl - alcohol, and can irreversibly harm nerves.(6,7) Awareness of benzyl alcohol's toxicity goes back to 1918 at least; it was proposed as an effective insecticide, and was found to be toxic to many animal systems. The safe systemic dose(7) is exceeded with an injection of 150 mg. of progesterone, yet the local concentration is far higher. It can cause a severe reaction even when used at a lower concentration, in bacteriostatic water.(5)

Other alcohols, including ethanol, have been used as solvents, but since they (ethanol even more than benzyl alcohol) have an affinity for water, the solution decomposes in contact with tissue water. In spite of the toxicity of the vehicle, several beneficial effects can be obtained with injected progesterone, in serious conditions such as epilepsy or cancer of the breast or uterus. Many researchers have commented on the very obvious difficulty of giving very large amounts of progesterone.(8) My comparisons of oral progesterone in tocopherol with other forms and methods of administration show a roughly similar efficiency for oral and injected progesterone, and about 1/20 the effect for suppositories. Crystals of progesterone are visible in the suppositories I have examined, and this material is obviously wasted.

An old theory of vitamin E's mechanism of action in improving fertility was that it spares progesterone.(9) It is established that some of the effects of vitamin E and progesterone are similar; for example, both prevent oxygen waste and appear to improve mitochondrial coupling of phosphorylation with respiration. I suspected that if they actually both work at the same mitochondrial site, then they must have a high mutual solubility. Knowing the long-standing problem of administering large doses of progesterone without a toxic solvent, I applied for and was granted a patent for the composition of progesterone in tocopherol. One of my reasons for publishing in the form of patents is that I have had many years of experience in having my discoveries taken up by others without acknowledgment. My dissertation research, which established that an estrogen excess kills the embryo by suffocation, and that progesterone protects the embryo by promoting the delivery of both  oxygen and glucose, didn't strike a responsive chord in the journals which are heavily influenced by funds from the drug industry.

According to a consultant for a major medical journal, the idea "... of dissolving progesterone, a fat soluble steroid hormone, in vitamin E which is then incorporated into chylormicrons absorbed via the lymphatics, and thus avoids the liver on the so called first pass... so simple it is amazing that the pharmaceutical companies have not jumped on it " 

In the powder form, direct and intimate contact with a mucous membrane allows lipid phase to lipid phase transfer of progesterone molecules. Instead of by-passing the liver, much of the progesterone is picked up in the portal circulation, where a major part of it is glucuronidated, and made water soluble for prompt -excretion. Since this glucuronide form cross-reacts to some extent with ordinary progesterone in the assay process, and since 50% of the ordinary free progesteronee is carried inside the red blood cells,(10, 11) and 50% is associated with proteins in the plasma, while the golucuronide hardly enters the red blood cells at all, it is better to judge by clinical efficacy when comparing different oral forms. My comparisons show several times higher potency in the tocopherol composition than in powder form.

Since progesterone's use as a drug antedates the 1938 law requiring special federal approval, its legal status is similar to that of thyroid hormone. Unfortunately for both thyroid and progesterone, there is a tendency to cut corners for the sake of a bigger profit margin.

For example, steroid acetates are generally a little cheaper than the simple natural steroid. Some people assume that an acetate or butyrate can be substituted for the steroid itself This can cause dangerous reactions.

Medroxyprogesterone acetate is considered a progestin (though it is not supportive of gestation), because it modifies the uterus in approximately the way progesterone does, but it is luteolytic, and lowers the ovaries' production of progesterone while progesterone itself has a positive effect on the corpus luteum, stimulating progesterone synthesis. Defining "progestin" in a narrow way allows many synthentics to be sold as progestagens, though some of them are strongly estrogenic, allowing them to function as contraceptives--it is odd that contraceptives and agents which suppress progesterone synthesis should be officially called "supporters of pregnancy," It is probably partly the acetate group in the medroxyprogesterone acetate molecule which makes it bind firmly to receptors, yet causes it to block the enzymes which would normally be involved in progesterone metabolism. (I think testosterone, even, might be a safer progestin than medroxyprogesterone  acetate.) Pregnenolone acetate similarly blocks the enzymes which normally metabolize pregnenolone.(12)  In aspirin, it has been found that It is the acetyl group which (by a free radical action) blocks an enzyme involved in prostaglandin synthesis.

If the category called "progestogens" or "progestins" is to be defined on the basis of a single tissue reaction, then it is possible to classify progesterone with the toxic synthetic substances, but then it becomes highly deceptive to imply that progesterone is just a progestin, or that it has any of the other properties of the toxic synthetics, but this continues to be done. The warnings about "progestins causing birth defects," for example, cause epileptic women to use conventional anti-seizure drugs (all of which cause birth defects) during pregnancy, and to avoid natural progesterone, which generally could control their seizures. Thus, a false message attached to progesterone creates precisely the harm it claims to want to prevent. In my communications with the regulatory agencies, I have concluded that their attempts to deceive are too blatant to ascribe to incompetency. Whether it's the Forest Service or the FDA, the principle is the same: the regulatory agencies have been captured by the regulated industries.

Another place to cut costs is in the tocopherol. Tocopherol acetate does have vitamin E activity, but since it is only about half as efficiently absorbed as the simple tocopherol,(13) it is a mistake to save a few dollars an ounce, at the expense of losing half of the therapeutic effect. People who have compared natural progesterone in natural tocopherols  with other compositions have insisted that the other compositions must not contain progesterone.

The taste of natural vitamin E is stronger than that of the synthetic forms, but since the mixture is absorbed by any tissue it contacts, including various parts of the bowel, it can be taken in a capsule. If a small amount of olive oil is used with it, absorption through the skin is very rapid. Many women use it vaginally, spread onto a diaphragm, to hold it in contact with the membranes. The efficiency of absorption by all routes is so high that patients should be warned against its anesthetic effect, until their dosage requirement is known approximately. Some physicians prefer concentrations higher than 10%, but the risk of accidental drunkenness or anesthesia is higher with the stronger solutions.

It is an indication of the tocopherol solution's high availability that medical researchers such as Roy Hertz,(8) who thought they were administering maximal doses by combining Injections with suppositories, never mentioned the problem of an anesthetic effect from an overdose. Similarly, it is evidence of the extremely poor availabilitv of the micropulverized progesterone that the researchers have administered hundreds of milligrams per day, without mentioning the symptoms of an overdose. Because of the. difficulties involved in scientifically studying the clinical effectiveness of various formulations, I think the most practical way of evaluating the effectiveness of different progesterone formulations is to measure the amount extractable from the fed blood cells, a few hours after the peak serum level has been reached. This will reasonably reflect the amounts reaching brain cells, adrenal glands, and the various other cells on which progesterone has its therapeutic action.


I . A. A. Gidley-Baird, et aL, Failure of implantation in human in vitro fertilization and embryo transfer patients: the effects of altered progesterone/estrogen ratios in humans and mice,  Fertility and sterility 45(1): 69-74. 1986.

2. J. L. Yovich, et al., Early luteal serum progesterone concentrations are higher in pregnancy cycles, Fertility and Sterility 44(l): 185-189, 1985.

3 . C. Djerassi, The making of the pill.  Science 84: 127-129, 1984.

4. R. Kehl, Les Glaudes Endocrines Presses Universitaires de France, Paris, 1952

5. J. A. Grant, et al., New England Journal of Medicine 306(2): 108, 1982, Unsuspected benzyl alcohol hypersensitivity.

6.T.E. Feasby. et al., Neurotoxicity of bacteriostatic water, New England Journal of Medicine 308(6): 966-7, 1983,

7. F. T. Kimura, et al., Parenteral toxicity, studies with benzyl alcobol, Toxicol Appl Pharmacol I8: 60-68, 1971.

8 A. White editor, Symposium on Steroids In Experimental and clinical Practice. The Blakiston Co., NY., 1951, p. 401.

9. A. Fraschini, 11 Metodo Biologico di Rinvigorimento, Edizioni Minerva Medica, Milan, 1954.

10 F.- Mulder, et al., Metabolism of free and conjugated steroids by intact and haemolysed mammalian erythrocytes, Biochim. Biophys. Acta 263: 290-297, 1972.

11. M. Holzbauer, The association of steroids with blood cells in vivo J. of Steroid Biochemistry 3: 579-592 1972.

12. S. Lieberman, et al., A heuristic proposal for understanding steroidogenic processes, Endocrine Reviews 5(1):  128-148, 1984.

13. L. J. Machlin and E. Gabriel, Kinetics of tissue alpha-tocopherol uptake and depletion, following administration of high levels of vitamin E, p. 48 in Annals of the N.Y. Academy of Science 393, B. Lubin and L. J. Machlin, editors, New York. 1982."

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