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LI 160 -- German St. John's Wort

We no longer sell this product!  We now sell 5-htp an immediate precussor to serritonin.  See |5-htp|.

LI 160 St. John's Wort, 45 Tablets, 300 mg 

These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, cure, treat or prevent any disease. If pregnant or lactating, consult a physician before using.

Frequently Asked Questions and Answers

 
bulletHow is LI 160, the product we sell, different than other St. John's wort formulas?
bulletWhy is clinical proof important?
bulletWhat can I expect after taking LI 160 for two to four weeks?
bulletWhy is it important to follow dosage instructions so closely?
bulletIs LI 160 for everybody?
bulletHow safe is this product?
bulletIs LI 160 an MAO Inhibitor?
bulletWant more technical info on St. John's Wort?
bulletWant a good book by a researcher at the National Institutes of Health?  

 

The product we sell, imported from Germany, contains the special formula LI 160 (used in most European clinicical trials), the only formula proven in 23 clinical studies to maintain a healthy emotional balance. This product from Lichtwer Pharma, is manufactured through a standardized, pharmaceutical-grade process so you're guaranteed a consistent dose in every single tablet. It is as effective as most hard anti depressant drugs such as Prozac®

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Why is clinical proof important?

Clinical studies are a means of testing herbal supplements like this to judge their effectiveness. LI 160 formula has been the most widely tested in independent clinical studies. The findings have been reported in medical journals and have confirmed that it is safe and effective in helping people maintain a healthy emotional balance and well-being.

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What can I expect after taking LI 160 for two to four weeks?

If you're like most people, this products gentle effect can help your perspective, renew your confidence, and allow a comfortable level of control in your life to help get you back on track.

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Why is it important to follow dosage instructions so closely?

To get the same results that were achieved during clinical tests, you should take LI 160 as recommended. Allow time for it to work. Clinical results were observed after a period of two to four weeks during which time one  tablet was taken three times a day.

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Is LI 160 for everybody?

It is not for everybody. Everybody experiences lifes ups and downs but, if its been taking you longer to bounce back and feel like your old self again, LI 160 might help. It is not a Magic pill, but clinical studies have proven that, when taken as directed, it can help you regain control in your life and help maintain a healthy emotional balance.

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How safe is this product?

LI 160 is non-habit forming, has no sedative effects, does not interact with alcohol or caffeine, and has no known interactions with prescription drugs.

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Is LI 160 an MAO Inhibitor?

No. Although it was formerly believed that St. John's wort worked much like an inhibitor of the enzyme monoamine oxidase (MAO), more recent investigations into the mechanism of action of St. John's wort have revealed that it does not operate like an MAO inhibitor but rather inhibits the re- uptake of the brain's chemical messengers serotonin, norepmephrine and dopamine at the endings of nerve fibers.

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An Editorial from the Journal Of Geriatric Psychiatry and Neurology, Volume 7, Supplement 1

"As an extra feature this month, readers of the Journal of Geriatric Psychiatry and Neurology are receiving this Supplement that outlines some very exciting reports on a new pharmaceutical agent. Until 3 months ago, I had never heard of hypericum, but in reviewing these papers and other literature, I have been impressed with the potential of this compound as a therapeutic agent in the treatment of mild-to-moderate depressive illnesses, the kind of depressions that predominate in outpatient medical practices.

What is hypericum, or St. John's wort as it is often called? It is a preparation derived from a plant that has been used as a natural remedy since ancient times. Hypericum perforatum L. is a member of the Hypericaceae family, and the German name "Johanniskraut" is derived from its blossom time around St. John's Day, the 24th day of June. External use of the red oil obtained from hypericum blooms has been reported to promote wound healing in burns. For internal administration, tea preparations from the leaves or ready-prepared extracts are used to treat mild states of excitation and depressed mood. An interesting paper in this Supplement indicates that hypericum is as effective as light therapy as a treatment for seasonal affective disorders. It is unknown which of the many substances found in hypericum blooms are the active ones, but it is presumed that hypericin and pseudohypericin are probably involved in its therapeutic effects.

Antidepressant effects of hypericum have been confirmed in several clinical studies that have compared this compound to placebo as well as standard antidepressants such as imipramine and maprotiline. One of the most important features is that side effects are rarely observed. Allergic reactions occur rarely. This benign side effect profile may make hypericum a particularly attractive choice for treating mild-to-moderate depressions in our elderly patients.

As this series of papers points out, the underlying pharmacologic mechanism of action of hypericum remains unclear. Since it is presumed that depression is associated with changes in levels of neurotransmitters, particularly noradrenaline and serotonin, an action on neurotransmitter metabolism through inhibition of the enzymes principally involved in central catabolism of the catecholamines, including monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), is conceivable: at least one early study demonstrated that hypericum inhibited MAO-A and MAO-B. Unfortunately, these findings could not be confirmed and later studies (see Thiede and Walper as well as Bladt and Wagner in the Supplement) indicate that the amount of inhibition is probably not sufficient to explain the antidepressant effect of hypericum.

Since the active components of hypericum do not seem able to pass the blood-brain barrier, it is hypothesized that their primary site of action must lie outside the central nervous system, and that effects could be brought about by mediators capable of passing into cerebrospinal fluid. Thiele, Brink, and Ploch feel that actions on cells of the immune system, such as lymphocytes and monocytes, would be likely. They discuss modulation of cytokine expression and secondary activating effects on CRH (corticotropin releasing hormone) by hypericum extract as a possible mechanism of antidepressant action. CRH has been assigned a central role in recent models of the pathogenesis of various forms of depression associated with elevated levels of this hypothalamic peptide. An oversecretion of hypothalamic CRH can be demonstrated in patients with depression, together with an increased concentration of CRH in the cerebrospinal fluid. In addition, the number of central CRH receptors is reduced in depression.

Hypericum extracts produce reduction in serotonin receptor expression on cell surfaces in certain models (see Muller and Rossol). These authors feel that the reduced availability of serotonin receptors under the influence of hypericum and resulting impaired reuptake ability of the neurotransmitter serotonin into the cells may represent another possible mechanism of the antidepressant activity of hypericum extract. They point out that unlike classic antidepressants, which bind the neurotransmitter, hypericum extract might "block" the entry point, leading to an increased level of neurotransmitter and, therefore, an antidepressant effect.

While the precise mechanism of action remains to be determined, the results of the many studies outlined in this Supplement form an impressive body of evidence indicating that hypericum may well be a potentially useful agent to treat mild-to-moderate depressions. "
Michael A. Jenike, MD

To order a copy of this supplement call toll free 1-800-568-7281.  These are scientific papers.

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"Very interestingly, the situation in Germany is different. As an alternative to the tricyclics with a low side effect profile, german doctors prescribe high-dosage Hypericum extract preparations with increasing tendency. Right now, these Hypericum extract preparations (tablets based on dried extract of St. Johns wort) make up more than 25% of all prescriptions filled out in Germany for antidepressant drugs. The leading brand (Jarsin 300 also known as LI 160 or Kira For the US market) is presently the mostly prescribed single antidepressant in Germany (It is also the brand we import and offer for sale to you ),   The frequent use of Hypericurn extract preparations faced important scepticims and many pharmacologists and psychiatrists felt that depressed patients are treated with drugs, which are not yet sufficiently investigated. This criticism, already formulated a few years ago, led to the initiation of a rather rigorous research program, dealing with preclinical and clinical aspects of the efficacy of Hypericum extract as an antidepressant drug. The first results have been presented at an international meeting, in Munich on September 1996.

Even though research is still going on, the available data show that Hypericurn extract is clinically effective as an antidepressant drug and that it probably works by biochemical mechanisms not so much different from the mechanisms of action of the tricyclics or the SSRI's. We feel that these findings are important enough to be communicated and interesting enough to stimulate further research". Walter E. Muller
Frankfurt Siegfried Kasper. Vienna

The proceedings of this meeting are summarized in the supplement. Pharmacopsychiat. 30 (1997) (Supplement) 71 C Georg Thieme Verlag Stuttgart - New York

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The Herbal Way To Feel good.
To order this book, which is highly recommended and is just $16.80, just click on the image.

stjohnwortrosenthal.gif (10427 bytes)

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